SOLUTION: Next Gen Celecoxib without Opioid addiction

While opioids will certainly continue to have a place in pain management despite their disadvantages, the use of non-opioid medication options may limit the amount of opioid necessary or even result in improved pain control. In fact, given that the majority of both acute and chronic pain is thought to be complex and multifactorial, a multimodal analgesic approach is ideal for management. Non-steroidal Anti-inflammatory Drugs (NSAIDs) are widely used analgesic. Osteoarthritis, rheumatoid arthritis, and headaches, are common conditions that NSAIDs treat. COX-2 inhibitors are a newer class of prescription-strength NSAIDs. Examples of COX-2 inhibitors are celecoxib (Celebrex) and meloxicam (Mobic). However the use of high dose celecoxib as an alternative to opioid to treat pain is associated with increased cardiovascular risk. To counter the side effect of celecoxib we used our proprietary PLD database to define olmesartan and celecoxib as frequently co-prescribed drugs that would limit the side effects of celecoxib. These are being developed as IT-102 and IT-103, respectively.

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